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The concept of amputation, prosthetic, orthotic fitting and orthopaedic rehabilitation on large animals is an innovative practice developed by the author. The author has developed several techniques of fitting of prosthetic and orthotic appliances for the large animals. The practical lessons and illustrations included in the book will be of very much of use for the students, teachers and researchers and practitioners in Veterinary Science in general and surgery in particular, covering details of surgical techniques in a brief manner with pictorial representation. The basic idea behind this book is to publish innovative methods and new affective techniques that are easy successful and cost effective. In orthopaedic treatment in large animals fitting of artificial limbs, prosthetic and orthotic appliances, amputation and rehabilitation appear to be very rare and complicated. Large numbers of hand drawings and photographs have been incorporated in order to visualize the surgical techniques for better understanding. Fabrication of modified Thomas Splint has been demonstrated step wise using illustrations. Use of conjoined ‘U’ plate for better immobilization in case of lower limb fabrication in large animals is claimed as an innovative step. A sling has been fabricated for lifting of downed large animals for making them mobile to facilitate exercise of unused and paralyzed limbs using locally available materials to make it cost effective as well as availability in most rural interiors.