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Synopsis The present volume is the compendium of research papers deliberated in a three-day conference during the silver jubilee celebration of the Institute for research in Medical Statistics and the XX Annual Conference of the Indian Society for Medical Statistics in December 2002. It contains 40 articles illustrating wide spectrum of Biostatistical research. Most of the articles cover methodological issues pertaining to health and population and are arranged under 4 major sections –biostatistical methods, epidemiology, health, population and related issues. The volume is an update of biostastical research. It is hoped that the book will promote exchange of ideas and motivate researchers, programme personnel and policy makers to understand and develop new tools in several areas of human health and motivate all sciences is advancing humanity. The book is dedicated to the memory of the late Professor P.V. Sukhatme and late Professor K.B. Pathak, renowned applied statisticians of India and former chairman of the Scientific Advisory Committee of the Institute for Research in medical Statistics ICMR, New Delhi.