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Synopsis The subject of drug is as old as disease and illness has been man’s heritage right from the beginning of his existence. The beginning of medicine and pharmacy are so closely interwoven with superstition and fact that it is different to separate and real from mythical.  Drug manufacturing part of Ayurveda is dealt in Rasasastra and Bhaijhalo kpalpana.  They deal with drug identification.  Sections, collection, preservation,, Processing, storage, product analysis, efficacy, toxicity and safety evaluation, dose determination, clinical evaluation and finally its clinical application.  Earlier, it was not a separate subject or independent branch of learning.  It was a part if the study of Ayurveda and along with the clinical subject.  Learning in drug manufacturing is imparted to learners of Ayurveda as practicing physician used to prepare the medicine on his own according to the need and suitability of his patients.  In the course of time, with the increasing population, busy life style and with the patient showing more inclination to obtain readymade drug from the manufacturer instead of from the physician, physician started depending on pharmaceutical industry of his drug requirement.  With the changing times and trends, the subject matter of Ayurvedic drug manufacturing was also classified as a separate subject specialization as Rasasastra and Bhaishajya Kalpana to provide a better and detailed knowledge with Rasasastra dealing with metallic, herbomieral drugs and Bhaishajya Kalpana with mostly drugs of herbal origin.