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Synopsis There is no controversy, whatsoever, over the enormity of problems in relation to HIV and AIDS on the social, clinical, public health and on the economic frontiers. Globally, since the first AIDS case was detected in USA in 1981, the HIV/AIDS epidemic continues its expansion across the globe with approx. 16000 new infections a day. The most rapidly spreading virulent virus infection and its related syndromes are yet the most misunderstood issues in Science. With numerous research material, documents surveillance and study reports from all over the world, a compilation of the facts and figures in the form of an encyclopaedia is need of the time. Readers may send their opinions, comments, and to the Editor on the subject for incorporating in the future editions. Their contribution will be duly acknowledge by me.